Clustered rapid induction of apoptosis limits ZIKV and DENV-2 proliferation in the midguts of Aedes aegypti

Jasmine B. Ayers; Heather G. Coatsworth; Seokyoung Kang; Rhoel R. Dinglasan; Lei Zhou

doi:10.1038/s42003-020-01614-9

Communications Biology (Jan 2021)

Clustered rapid induction of apoptosis limits ZIKV and DENV-2 proliferation in the midguts of Aedes aegypti

Jasmine B. Ayers,
Heather G. Coatsworth,
Seokyoung Kang,
Rhoel R. Dinglasan,
Lei Zhou

Affiliations

Jasmine B. Ayers: Emerging Pathogens Institute, University of Florida
Heather G. Coatsworth: Emerging Pathogens Institute, University of Florida
Seokyoung Kang: Emerging Pathogens Institute, University of Florida
Rhoel R. Dinglasan: Emerging Pathogens Institute, University of Florida
Lei Zhou: Emerging Pathogens Institute, University of Florida

DOI: https://doi.org/10.1038/s42003-020-01614-9
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 9

Abstract

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Ayers et al. report rapid induction of apoptosis in the midgut of Aedes aegypti mosquitoes within 2 hours of infection by dengue and Zika viruses, and find that inhibiting apoptosis led to increased virus proliferation in the midgut. These results suggest rapid induction of apoptosis as an innate immune mechanism mediating midgut infection in this mosquito vector.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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