Nature Communications (May 2019)
GWAS of bone size yields twelve loci that also affect height, BMD, osteoarthritis or fractures
- Unnur Styrkarsdottir,
- Olafur A. Stefansson,
- Kristbjorg Gunnarsdottir,
- Gudmar Thorleifsson,
- Sigrun H. Lund,
- Lilja Stefansdottir,
- Kristinn Juliusson,
- Arna B. Agustsdottir,
- Florian Zink,
- Gisli H. Halldorsson,
- Erna V. Ivarsdottir,
- Stefania Benonisdottir,
- Hakon Jonsson,
- Arnaldur Gylfason,
- Kristjan Norland,
- Katerina Trajanoska,
- Cindy G. Boer,
- Lorraine Southam,
- Jason C. S. Leung,
- Nelson L. S. Tang,
- Timothy C. Y. Kwok,
- Jenny S. W. Lee,
- Suzanne C. Ho,
- Inger Byrjalsen,
- Jacqueline R. Center,
- Seung Hun Lee,
- Jung-Min Koh,
- L. Stefan Lohmander,
- Lan T. Ho-Pham,
- Tuan V. Nguyen,
- John A. Eisman,
- Jean Woo,
- Ping-C. Leung,
- John Loughlin,
- Eleftheria Zeggini,
- Claus Christiansen,
- Fernando Rivadeneira,
- Joyce van Meurs,
- Andre G. Uitterlinden,
- Brynjolfur Mogensen,
- Helgi Jonsson,
- Thorvaldur Ingvarsson,
- Gunnar Sigurdsson,
- Rafn Benediktsson,
- Patrick Sulem,
- Ingileif Jonsdottir,
- Gisli Masson,
- Hilma Holm,
- Gudmundur L. Norddahl,
- Unnur Thorsteinsdottir,
- Daniel F. Gudbjartsson,
- Kari Stefansson
Affiliations
- Unnur Styrkarsdottir
- deCODE genetics/Amgen Inc.
- Olafur A. Stefansson
- deCODE genetics/Amgen Inc.
- Kristbjorg Gunnarsdottir
- deCODE genetics/Amgen Inc.
- Gudmar Thorleifsson
- deCODE genetics/Amgen Inc.
- Sigrun H. Lund
- deCODE genetics/Amgen Inc.
- Lilja Stefansdottir
- deCODE genetics/Amgen Inc.
- Kristinn Juliusson
- deCODE genetics/Amgen Inc.
- Arna B. Agustsdottir
- deCODE genetics/Amgen Inc.
- Florian Zink
- deCODE genetics/Amgen Inc.
- Gisli H. Halldorsson
- deCODE genetics/Amgen Inc.
- Erna V. Ivarsdottir
- deCODE genetics/Amgen Inc.
- Stefania Benonisdottir
- deCODE genetics/Amgen Inc.
- Hakon Jonsson
- deCODE genetics/Amgen Inc.
- Arnaldur Gylfason
- deCODE genetics/Amgen Inc.
- Kristjan Norland
- deCODE genetics/Amgen Inc.
- Katerina Trajanoska
- Department of Epidemiology, ErasmusMC
- Cindy G. Boer
- Department of Internal Medicine, ErasmusMC
- Lorraine Southam
- Wellcome Trust Sanger Institute
- Jason C. S. Leung
- Jockey Club Centre for Osteoporosis Care and Control, Faculty of Medicine, The Chinese University of Hong Kong
- Nelson L. S. Tang
- Faculty of Medicine, Department of Chemical Pathology and Laboratory for Genetics of Disease Susceptibility, Li Ka Shing Institute of Health Sciences,, The Chinese University of Hong Kong
- Timothy C. Y. Kwok
- Jockey Club Centre for Osteoporosis Care and Control, Faculty of Medicine, The Chinese University of Hong Kong
- Jenny S. W. Lee
- Faculty of Medicine, Department of Medicine and Therapeutics, The Chinese University of Hong Kong
- Suzanne C. Ho
- JC School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong
- Inger Byrjalsen
- Nordic Bioscience A/S
- Jacqueline R. Center
- Bone Biology Division, Garvan Institute of Medical Research
- Seung Hun Lee
- Division of Endocrinology and Metabolism, Asan Medical Center, University of Ulsan College of Medicine
- Jung-Min Koh
- Division of Endocrinology and Metabolism, Asan Medical Center, University of Ulsan College of Medicine
- L. Stefan Lohmander
- Orthopaedics, Department of Clinical Sciences Lund, Lund University
- Lan T. Ho-Pham
- Bone and Muscle Research Lab, Ton Duc Thang University
- Tuan V. Nguyen
- Bone Biology Division, Garvan Institute of Medical Research
- John A. Eisman
- Bone Biology Division, Garvan Institute of Medical Research
- Jean Woo
- Faculty of Medicine, Department of Medicine and Therapeutics, The Chinese University of Hong Kong
- Ping-C. Leung
- Jockey Club Centre for Osteoporosis Care and Control, Faculty of Medicine, The Chinese University of Hong Kong
- John Loughlin
- Institute of Genetic Medicine, Newcastle University
- Eleftheria Zeggini
- Wellcome Trust Sanger Institute
- Claus Christiansen
- Nordic Bioscience A/S
- Fernando Rivadeneira
- Department of Epidemiology, ErasmusMC
- Joyce van Meurs
- Department of Internal Medicine, ErasmusMC
- Andre G. Uitterlinden
- Department of Internal Medicine, ErasmusMC
- Brynjolfur Mogensen
- Faculty of Medicine, University of Iceland
- Helgi Jonsson
- Faculty of Medicine, University of Iceland
- Thorvaldur Ingvarsson
- Faculty of Medicine, University of Iceland
- Gunnar Sigurdsson
- Faculty of Medicine, University of Iceland
- Rafn Benediktsson
- Faculty of Medicine, University of Iceland
- Patrick Sulem
- deCODE genetics/Amgen Inc.
- Ingileif Jonsdottir
- deCODE genetics/Amgen Inc.
- Gisli Masson
- deCODE genetics/Amgen Inc.
- Hilma Holm
- deCODE genetics/Amgen Inc.
- Gudmundur L. Norddahl
- deCODE genetics/Amgen Inc.
- Unnur Thorsteinsdottir
- deCODE genetics/Amgen Inc.
- Daniel F. Gudbjartsson
- deCODE genetics/Amgen Inc.
- Kari Stefansson
- deCODE genetics/Amgen Inc.
- DOI
- https://doi.org/10.1038/s41467-019-09860-0
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 13
Abstract
Size and shape of bones are important for height and body shape. Here, Styrkarsdottir et al identify 12 loci in a GWAS for bone area derived from DXA scans and show that these loci associate with other bone-related phenotypes including osteoarthritis, height, bone mineral density and risk of hip fracture.
