Generation of an induced pluripotent stem cell line (SDQLCHi067-A) from a patient with subcortical band heterotopia harboring a heterozygous mutation in DCX gene

Chunlai Gao; Xiaomeng Yang; Yanan Yang; Ning Liu; Yue Li; Yi Liu; Zhongtao Gai

Stem Cell Research (Apr 2024)

Generation of an induced pluripotent stem cell line (SDQLCHi067-A) from a patient with subcortical band heterotopia harboring a heterozygous mutation in DCX gene

Chunlai Gao,
Xiaomeng Yang,
Yanan Yang,
Ning Liu,
Yue Li,
Yi Liu,
Zhongtao Gai

Affiliations

Chunlai Gao: Pediatric Research Institute, Children’s Hospital Affiliated to Shandong University, Jinan, Shandong 250022, China; Pediatric Research Institute, Jinan Children’s Hospital, Jinan, Shandong 250022, China
Xiaomeng Yang: Pediatric Research Institute, Children’s Hospital Affiliated to Shandong University, Jinan, Shandong 250022, China; Pediatric Research Institute, Jinan Children’s Hospital, Jinan, Shandong 250022, China
Yanan Yang: Pediatric Research Institute, Children’s Hospital Affiliated to Shandong University, Jinan, Shandong 250022, China; Pediatric Research Institute, Jinan Children’s Hospital, Jinan, Shandong 250022, China
Ning Liu: Pediatric Research Institute, Children’s Hospital Affiliated to Shandong University, Jinan, Shandong 250022, China; Pediatric Research Institute, Jinan Children’s Hospital, Jinan, Shandong 250022, China
Yue Li: Pediatric Research Institute, Children’s Hospital Affiliated to Shandong University, Jinan, Shandong 250022, China; Pediatric Research Institute, Jinan Children’s Hospital, Jinan, Shandong 250022, China
Yi Liu: Pediatric Research Institute, Children’s Hospital Affiliated to Shandong University, Jinan, Shandong 250022, China; Pediatric Research Institute, Jinan Children’s Hospital, Jinan, Shandong 250022, China; Corresponding authors at: Pediatric Research Institute, Jinan Children’s Hospital, Jinan, Shandong 250022, China..
Zhongtao Gai: Pediatric Research Institute, Children’s Hospital Affiliated to Shandong University, Jinan, Shandong 250022, China; Pediatric Research Institute, Jinan Children’s Hospital, Jinan, Shandong 250022, China; Corresponding authors at: Pediatric Research Institute, Jinan Children’s Hospital, Jinan, Shandong 250022, China..

Journal volume & issue: Vol. 76
p. 103356

Abstract

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Subcortical band heterotopia (SHB) is a rare severe brain developmental malformation caused by deficient neuronal migration during the development of cerebral cortex. Here, a human induced pluripotent stem cell (iPSCs) line was established from a 4-year-1-month-old girl with SHB carrying a heterozygous mutation (c.568A > G, p.K190E) in DCX. The generated iPSC line showed the ability to differentiate into three lineages in vitro and was confirmed by pluripotency markers and the original gene mutation.

Published in Stem Cell Research

ISSN: 1873-5061 (Print); 1876-7753 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Biology (General)
Website: https://www.journals.elsevier.com/stem-cell-research

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