Nature Communications (Apr 2021)
SLPI is a critical mediator that controls PTH-induced bone formation
- Akito Morimoto,
- Junichi Kikuta,
- Keizo Nishikawa,
- Takao Sudo,
- Maki Uenaka,
- Masayuki Furuya,
- Tetsuo Hasegawa,
- Kunihiko Hashimoto,
- Hiroyuki Tsukazaki,
- Shigeto Seno,
- Akira Nakamura,
- Daisuke Okuzaki,
- Fuminori Sugihara,
- Akinori Ninomiya,
- Takeshi Yoshimura,
- Ryoko Takao-Kawabata,
- Hideo Matsuda,
- Masaru Ishii
Affiliations
- Akito Morimoto
- Department of Immunology and Cell Biology, Graduate School of Medicine and Frontier Biosciences, Osaka University
- Junichi Kikuta
- Department of Immunology and Cell Biology, Graduate School of Medicine and Frontier Biosciences, Osaka University
- Keizo Nishikawa
- Department of Immunology and Cell Biology, Graduate School of Medicine and Frontier Biosciences, Osaka University
- Takao Sudo
- Department of Immunology and Cell Biology, Graduate School of Medicine and Frontier Biosciences, Osaka University
- Maki Uenaka
- Department of Immunology and Cell Biology, Graduate School of Medicine and Frontier Biosciences, Osaka University
- Masayuki Furuya
- Department of Immunology and Cell Biology, Graduate School of Medicine and Frontier Biosciences, Osaka University
- Tetsuo Hasegawa
- Department of Immunology and Cell Biology, Graduate School of Medicine and Frontier Biosciences, Osaka University
- Kunihiko Hashimoto
- Department of Immunology and Cell Biology, Graduate School of Medicine and Frontier Biosciences, Osaka University
- Hiroyuki Tsukazaki
- Department of Immunology and Cell Biology, Graduate School of Medicine and Frontier Biosciences, Osaka University
- Shigeto Seno
- Department of Bioinformatic Engineering, Graduate School of Information Science and Technology, Osaka University
- Akira Nakamura
- Division of Immunology, Tohoku Medical and Pharmaceutical University
- Daisuke Okuzaki
- WPI-Immunology Frontier Research Center, Osaka University
- Fuminori Sugihara
- Core Instrumentation Facility, Immunology Frontier Research Center and Research Institute for Microbial Diseases, Osaka University
- Akinori Ninomiya
- Core Instrumentation Facility, Immunology Frontier Research Center and Research Institute for Microbial Diseases, Osaka University
- Takeshi Yoshimura
- Medical Affairs Department, Asahi Kasei Pharma Corporation
- Ryoko Takao-Kawabata
- Laboratory for Pharmacology, Pharmaceuticals Research Center, Asahi Kasei Pharma Corporation
- Hideo Matsuda
- Department of Bioinformatic Engineering, Graduate School of Information Science and Technology, Osaka University
- Masaru Ishii
- Department of Immunology and Cell Biology, Graduate School of Medicine and Frontier Biosciences, Osaka University
- DOI
- https://doi.org/10.1038/s41467-021-22402-x
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 14
Abstract
The mechanism by which parathyroid hormone mediates the switch from bone resorption to bone formation is unclear. Here, the authors show that SLPI regulates the communication between osteoblasts and osteoclasts to promote the anabolic effect of parathyroid hormone.
