Nature Communications (Jun 2020)
Dual Role of WISP1 in maintaining glioma stem cells and tumor-supportive macrophages in glioblastoma
- Weiwei Tao,
- Chengwei Chu,
- Wenchao Zhou,
- Zhi Huang,
- Kui Zhai,
- Xiaoguang Fang,
- Qian Huang,
- Aili Zhang,
- Xiuxing Wang,
- Xingjiang Yu,
- Haidong Huang,
- Qiulian Wu,
- Andrew E. Sloan,
- Jennifer S. Yu,
- Xiaoxia Li,
- George R. Stark,
- Jeremy N. Rich,
- Shideng Bao
Affiliations
- Weiwei Tao
- Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic
- Chengwei Chu
- Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic
- Wenchao Zhou
- Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic
- Zhi Huang
- Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic
- Kui Zhai
- Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic
- Xiaoguang Fang
- Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic
- Qian Huang
- Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic
- Aili Zhang
- Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic
- Xiuxing Wang
- Division of Regenerative Medicine, Department of Medicine, University of California, San Diego
- Xingjiang Yu
- Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic
- Haidong Huang
- Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic
- Qiulian Wu
- Division of Regenerative Medicine, Department of Medicine, University of California, San Diego
- Andrew E. Sloan
- Brain Tumor and Neuro-Oncology Center, Seidman Cancer Center, University Hospitals, Case Western Reserve University
- Jennifer S. Yu
- Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic
- Xiaoxia Li
- Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine
- George R. Stark
- Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic
- Jeremy N. Rich
- Division of Regenerative Medicine, Department of Medicine, University of California, San Diego
- Shideng Bao
- Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic
- DOI
- https://doi.org/10.1038/s41467-020-16827-z
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 16
Abstract
The tumour microenvironment plays an important role in promoting glioblastoma. Here, the authors show that glioma stem cells secrete WISP1, which promotes both the survival of the stem cells and tumour-associated macrophages.
