Nature Communications (Dec 2017)
Lipid bodies containing oxidatively truncated lipids block antigen cross-presentation by dendritic cells in cancer
- Filippo Veglia,
- Vladimir A. Tyurin,
- Dariush Mohammadyani,
- Maria Blasi,
- Elizabeth K. Duperret,
- Laxminarasimha Donthireddy,
- Ayumi Hashimoto,
- Alexandr Kapralov,
- Andrew Amoscato,
- Roberto Angelini,
- Sima Patel,
- Kevin Alicea-Torres,
- David Weiner,
- Maureen E. Murphy,
- Judith Klein-Seetharaman,
- Esteban Celis,
- Valerian E. Kagan,
- Dmitry I. Gabrilovich
Affiliations
- Filippo Veglia
- Translational Tumor Immunology Program, The Wistar Institute
- Vladimir A. Tyurin
- Department of Environmental and Occupational Health, University of Pittsburgh
- Dariush Mohammadyani
- Department of Environmental and Occupational Health, University of Pittsburgh
- Maria Blasi
- Duke University Medical Center
- Elizabeth K. Duperret
- Translational Tumor Immunology Program, The Wistar Institute
- Laxminarasimha Donthireddy
- Translational Tumor Immunology Program, The Wistar Institute
- Ayumi Hashimoto
- Translational Tumor Immunology Program, The Wistar Institute
- Alexandr Kapralov
- Department of Environmental and Occupational Health, University of Pittsburgh
- Andrew Amoscato
- Department of Environmental and Occupational Health, University of Pittsburgh
- Roberto Angelini
- Department of Environmental and Occupational Health, University of Pittsburgh
- Sima Patel
- Translational Tumor Immunology Program, The Wistar Institute
- Kevin Alicea-Torres
- Translational Tumor Immunology Program, The Wistar Institute
- David Weiner
- Translational Tumor Immunology Program, The Wistar Institute
- Maureen E. Murphy
- Program in Molecular and Cellular Oncogenesis, The Wistar Institute
- Judith Klein-Seetharaman
- Department of Environmental and Occupational Health, University of Pittsburgh
- Esteban Celis
- Cancer Immunology, Inflammation and Tolerance Program, Augusta University, Georgia Cancer Center
- Valerian E. Kagan
- Department of Environmental and Occupational Health, University of Pittsburgh
- Dmitry I. Gabrilovich
- Translational Tumor Immunology Program, The Wistar Institute
- DOI
- https://doi.org/10.1038/s41467-017-02186-9
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 16
Abstract
Tumor-associated dendritic cells are defective in their ability to cross-present antigens, and they accumulate lipid bodies. Here the authors show that this defect is due to an impaired trafficking of peptide-MHC class I caused by the interaction of electrophilic lipids with chaperone heat shock protein 70.
