Nature Communications (Nov 2017)

Regulatory T cells control toxicity in a humanized model of IL-2 therapy

  • Yan Li,
  • Helene Strick-Marchand,
  • Ai Ing Lim,
  • Jiazi Ren,
  • Guillemette Masse-Ranson,
  • Dan Li,
  • Gregory Jouvion,
  • Lars Rogge,
  • Sophie Lucas,
  • Bin Li,
  • James P. Di Santo

DOI
https://doi.org/10.1038/s41467-017-01570-9
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 12

Abstract

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High dose IL-2 is a viable treatment option for cancer immune therapy, but the underlying mechanism for the accompanying undesirable morbidity is unclear. Here the authors show, using human immune system mouse models, that regulatory T cells and their functions on effector T cells are essential modulators of the related pathogenesis.