Influence of chemerin rs17173608 polymorphism on polycystic ovary syndrome susceptibility

Abstract

Objective: The purpose of this study was to assess the association between the rs17173608 chemerin polymorphism and polycystic ovary syndrome risk (PCOS). Materials and methods: This case–control study was performed on 150 patients with PCOS and 150 normal women as the control group. Tetra-amplification refractory mutation system–polymerase chain reaction was used to detect the polymorphism. Results: Our finding showed a positive association between the chemerin gene rs17173608 polymorphism and risk of PCOS. In the dominant effect of the G allele (comparison between TG+GG and TT), TG+GG genotypes were associated with the risk of PCOS (odds ratio = 2; 95% confidence interval = 1.3–3.2, p = 0.003). The G allele is thus dominant and increases the risk of PCOS as compared to the T allele (odds ratio = 1.7, 95% confidence interval = 1.1–2.5, p = 0.009). Nonetheless, there was no significant association between chemerin rs17173608 gene polymorphism and PCOS after adjusting genotypes for body mass index and age. Conclusion: These results suggested that there was a significant association between chemerin rs17173608 polymorphism and the PCOS; but this relationship was affected by obesity status.

Keywords

• chemerin
• genetic obesity
• polycystic ovary syndrome
• polymorphism