Purinergic signalling in autoimmunity: A role for the P2X7R in systemic lupus erythematosus?

Francesco Di Virgilio; Anna Lisa Giuliani

Biomedical Journal (Oct 2016)

Purinergic signalling in autoimmunity: A role for the P2X7R in systemic lupus erythematosus?

Francesco Di Virgilio,
Anna Lisa Giuliani

Affiliations

Francesco Di Virgilio: Corresponding author. Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Via Savonarola, 9, Ferrara, FE 44121, Italy. Tel.: +39 0532 455353; fax: +39 0532 455351.; Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy
Anna Lisa Giuliani: Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy

Journal volume & issue: Vol. 39, no. 5
pp. 326 – 338

Abstract

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Purinergic signalling plays a crucial role in immunity and autoimmunity. Among purinergic receptors, the P2X7 receptor (P2X7R) has an undisputed role as it is expressed to high level by immune cells, triggers cytokine release and modulates immune cell differentiation. In this review, we focus on evidence supporting a possible role of the P2X7R in the pathogenesis of systemic lupus erythematosus (SLE). Keywords: Extracellular ATP, P2X7R, Systemic lupus erythematosus, NLRP3 inflammasome, Interleukin-1Î²

Published in Biomedical Journal

ISSN: 2319-4170 (Print); 2320-2890 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Medicine (General); Science: Biology (General)
Website: https://www.sciencedirect.com/journal/biomedical-journal

About the journal