Guoji laonian yixue zazhi (Jul 2024)
Effect of Stereotactic Minimally Invasive Surgery on Immune Level and Activities of Daily Living in Elderly Patients with Glioma
Abstract
Objective To investigate the effect of stereotactic minimally invasive surgery on immune level and activities of daily living in elderly patients with glioma. Methods Ninety elderly patients with glioma admitted to the First Affiliated Hospital of Harbin Medical University from March 2020 to February 2022 were selected as the study subjects and divided into two groups according to the random number table, 45 cases for each group. The control group was treated with conventional craniotomy and the observation group was treated with stereotactic minimally invasive surgery. The clinical efficacy, activities of daily living (ADL) score, National Institutes of Health Stroke Scale (NIHSS) score, peripheral blood immune parameters T helper (Th) 1, Th2 and Th17 levels were compared between the two groups. Results The overall response rate in the observation group was higher than that in the control group. The recurrence rate at 1 year after surgery was lower than that in the control group. After treatment, the ADL score in the observation group was higher than that in the control group, the NIHSS score was lower than that in the control group, the Th1 level was higher than that in the control group, and the Th2 and Th17 levels were lower than those in the control group. The differences were statistically significant (P<0.05). Conclusion Stereotactic minimally invasive surgery is effective in the treatment of glioma in the elderly, not only improving the immune function indicators and neurological deficits, but also helping to improve the activities of daily living, reduceing short-term recurrence rate.
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