Cancers (Mar 2020)

Optimal Body Mass Index Cut-off Point for Predicting Colorectal Cancer Survival in an Asian Population: A National Health Information Database Analysis

  • Nan Song,
  • Dan Huang,
  • Doeun Jang,
  • Min Jung Kim,
  • Seung-Yong Jeong,
  • Aesun Shin,
  • Ji Won Park

DOI
https://doi.org/10.3390/cancers12040830
Journal volume & issue
Vol. 12, no. 4
p. 830

Abstract

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The optimal body mass index (BMI) range for predicting survival in Asian colorectal cancer patients is unknown. We established the most appropriate cut-off point of BMI to predict better survival in Asian colorectal cancer patients using a two-stage approach. Two cohorts of colorectal cancer patients were included in this study: 5815 hospital-based development cohort and 54,043 nationwide validation cohort. To determine the optimal BMI cut-off point at diagnosis, the method of Contal and O’Quigley was used. We evaluated the association between BMI and overall survival (OS) using the Cox proportional hazard model. During a median follow-up of 5.7 and 5.1 years for the development and the validation cohort, 1180 (20.3%) and 10,244 (19.0%) deaths occurred, respectively. The optimal cut-off of BMI identified as 20.2 kg/m2 (plog-rank −16) for differentiating between poorer and better OS in the development cohort. When compared to the patients with a BMI 2, the patients with a BMI ≥ 20.2 kg/m2 had a significantly better OS (HR = 0.62, 95% CI = 0.54–0.72, p = 1.1 × 10−10). The association was validated in the nationwide cohort, showing better OS in patients with a BMI ≥ 20.2 kg/m2 (HR = 0.64, 95% CI = 0.60–0.67, p 2 to predict survival in Asian colorectal cancer patients.

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