A 3D Simulation and Experimental In-vitro Study of Magnetic Fluid Hyperthermia in a Tissue containing Micro and Macro Blood Perfusions.

Abstract

Exposed to an alternating magnetic flied, suspension of superparamagnetic nanoparticles begins heating due to two mechanisms: Neel relaxation and Brownian rotation. This heating effect is an appropriate candidate to be used in hyperthermia treatments of cancer. In this paper the heating effect of magnetic fluid in a porcine liver tissue is numerically analyzed and experimentally validated. Analysis reported in this paper is a three dimensional and transient simulation of magnetic fluid hyperthermia process for a tissue having a micro perfusion and also is near a large blood vessel. The temperature distribution in tissue is calculated for various micro and macro perfusion rates and their effects on the temperature profile are considered.

Keywords

• keywords: magnetic fluid hyperthermia
• neel relaxation
• brownian rotation
• superparamagnetic nanoparticles
• micro perfusion
• macro perfusion.