POSSIBILITY OF DRUG PREVENTION ANTHRACYCLINE-INDUCED CARDIOTOXICITY

Abstract

Purpose. To estimate the possibility of trimethylhydrasine propionate using for prevention of acute doxorubicin-induced cariotoxicity in breast cancer patients. Material and methods. The study included 72 women (mean age – 51 ± 2.1 years) with breast cancer without significant pathology of the cardiovascular system. Main group consisted of 32 patients (mean age – 52 ± 2.2 years), which were injected intravenously trimethylhydrasine propionate 1000 mg 1 times/day for three days prior to chemotherapy. 40 patients of the control group (mean age – 50 ± 2.5 years) did not receive of cardioprotective therapy before chemotherapy. For the cancer treatment of these patients used doxorubicin in dose of 50 mg/m2 per course in combination with various drugs. All patients were studied by GATE SPECT before starting chemotherapy and at 1 hour after the first administration of doxorubicin. Results. Before the start of chemotherapy, none of the patients showed perfusion defects and contractility disorders. Baselines left ventricular contractility in control group and in main group was not different. After doxorubicin administration in the control group there was a decrease in left ventricular ejection fraction (LVEF) – from 65.5 ± 9.8 % to 61.8 ± 7.2 % (p<0.05), increase in left ventricular end-systolic volume – from 30.8 ± 16.7 ml to 34.2 ± 17.0 ml (p<0.05), reduction in the peak ejection rate – from 3.2 ± 0.8 EDV/s to 2.4 ± 0.5 EDV/s (p<0.05). In the main group after first course of chemotherapy statistically significant changes of left ventricular contractile function were not found. After administration of doxorubicin was found that 31 % patients of main group and 40 % patients of control group had a considerable (10% or more) reduction in LVEF.

Keywords

• gate single photon emission tomography
• anthracycline-induced cardiotoxicity
• trimethylhydrasine propionate
• prevention of cardiotoxicity
• breast cancer