vASCULAR AND CARDIAC REMODELLING AND COMbINATION THERAPY OF ARTERIAL HYPERTENSION IN PATIENTS WITH CHRONIC ObSTRUCTIvE PULMONARY DISEASE

Abstract

Aim. To assess cardiac and vascular structure and function, blood flow parameters, endothelial dysfunction, and cytokine status in patients with arterial hypertension (Ah) and chronic obstructive pulmonary disease (COPD), who were administered combination Co-renitec therapy. Material and methods.The study included 37 patients with Ah and COPD, who underwent laboratory, functional, and ultrasound examination.Results.During the 6-month combination Co-renitec therapy, the parameters of clinical status, circadian blood pressure profile, and endothelial, vascular, and cardiac structure and function were assessed in patients with Ah and COPD.Conclusion. The combination Co-renitec therapy was associated with normalisedblood pressure levels, improved clinical and hemodynamic status, cardiac and vascular structure and function, and blood flow and microcirculation, as well as with reduced levels of the markers of endothelial dysfunction and systemic inflammation.

Keywords

• arterial hypertension, chronic obstructive pulmonary disease, cardiac and vascular remodelling, endothelial dysfunction, systemic inflammation, therapy effectiveness.