Neuroprotective effect of genistein against beta amyloid-induced neurotoxicity

Oh Young Bang; Hyun Seok Hong; Dong Hyun Kim; Hee Kim; Jung Hyun Boo; Kyoon Huh; Inhee Mook-Jung

Neurobiology of Disease (Jun 2004)

Neuroprotective effect of genistein against beta amyloid-induced neurotoxicity

Oh Young Bang,
Hyun Seok Hong,
Dong Hyun Kim,
Hee Kim,
Jung Hyun Boo,
Kyoon Huh,
Inhee Mook-Jung

Affiliations

Oh Young Bang: Department of Neurology, Suwon, South Korea; Brain Disease Research Center, College of Medicine, Ajou University, Suwon 442-721, Korea; Department of Biochemistry, Cancer Research Institute, Seoul National University College of Medicine, Seoul 110-799, Korea
Hyun Seok Hong: Department of Neurology, Suwon, South Korea; Brain Disease Research Center, College of Medicine, Ajou University, Suwon 442-721, Korea; Department of Biochemistry, Cancer Research Institute, Seoul National University College of Medicine, Seoul 110-799, Korea
Dong Hyun Kim: Department of Neurology, Suwon, South Korea; Brain Disease Research Center, College of Medicine, Ajou University, Suwon 442-721, Korea; Department of Biochemistry, Cancer Research Institute, Seoul National University College of Medicine, Seoul 110-799, Korea
Hee Kim: Department of Neurology, Suwon, South Korea; Brain Disease Research Center, College of Medicine, Ajou University, Suwon 442-721, Korea; Department of Biochemistry, Cancer Research Institute, Seoul National University College of Medicine, Seoul 110-799, Korea
Jung Hyun Boo: Department of Neurology, Suwon, South Korea; Brain Disease Research Center, College of Medicine, Ajou University, Suwon 442-721, Korea; Department of Biochemistry, Cancer Research Institute, Seoul National University College of Medicine, Seoul 110-799, Korea
Kyoon Huh: Department of Neurology, Suwon, South Korea; Brain Disease Research Center, College of Medicine, Ajou University, Suwon 442-721, Korea; Department of Biochemistry, Cancer Research Institute, Seoul National University College of Medicine, Seoul 110-799, Korea
Inhee Mook-Jung: Department of Neurology, Suwon, South Korea; Brain Disease Research Center, College of Medicine, Ajou University, Suwon 442-721, Korea; Department of Biochemistry, Cancer Research Institute, Seoul National University College of Medicine, Seoul 110-799, Korea

Journal volume & issue: Vol. 16, no. 1
pp. 21 – 28

Abstract

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Estrogen is beneficial to patients with Alzheimer's disease (AD) but has a limited clinical use due to its proliferative and oncogenic effects on non-neuronal cells responsive to estrogen. In an attempt to find an estrogen substitute that retains the beneficial effects of estrogen with minimal side effects, we compared the neuroprotective and proliferative effects of genistein, a selective estrogen receptor (ER) β-agonist, with those of estrogen. Genistein and 17β-estradiol showed comparable levels of protection against Aβ-induced deaths of cultured SH-SY5Y human neuroblastoma cells, which were blocked by an estrogen receptor antagonist, ICI 182,780. On the other hand, 17β-estradiol, but not genistein, induced proliferation of uterine endometrial cells. Our results suggest that genistein is a potential alternative to estrogen in the treatment of Alzheimer's disease.

Published in Neurobiology of Disease

ISSN: 0969-9961 (Print); 1095-953X (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.journals.elsevier.com/neurobiology-of-disease

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