New Briarane Diterpenoids from the Gorgonian Coral <em>Junceella juncea</em>

Abstract

Chemical investigation of <em>Junceella juncea</em> has resulted in the isolation of three new briaranes designated juncenolides M–O (<strong>1</strong>–<strong>3</strong>). The structures of these compounds were determined by spectroscopic analysis including 2D-NMR (COSY, HMBC and NOESY) and HRMS. Compound <strong>1 </strong>is<strong> </strong>a<strong> </strong>new chlorinated briarane while compound <strong>3</strong> contains a rare methyl ester at C-16. The anti-inflammatory activities tested on superoxide anion generation and elastase release by human neutrophils in response to FMLP/CB were evaluated.

Keywords

• &lt;em&gt;Junceella juncea&lt;/em&gt;
• briaranes
• anti-inflammatory activity