Biogenesis and functions of aminocarboxypropyluridine in tRNA

Mayuko Takakura; Kensuke Ishiguro; Shinichiro Akichika; Kenjyo Miyauchi; Tsutomu Suzuki

doi:10.1038/s41467-019-13525-3

Nature Communications (Dec 2019)

Biogenesis and functions of aminocarboxypropyluridine in tRNA

Mayuko Takakura,
Kensuke Ishiguro,
Shinichiro Akichika,
Kenjyo Miyauchi,
Tsutomu Suzuki

Affiliations

Mayuko Takakura: Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo
Kensuke Ishiguro: Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo
Shinichiro Akichika: Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo
Kenjyo Miyauchi: Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo
Tsutomu Suzuki: Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo

DOI: https://doi.org/10.1038/s41467-019-13525-3
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 12

Abstract

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E. coli and human tRNAs contain 3-(3-amino-3-carboxypropyl)uridine (acp3U) modification. Here the authors identify E. coli TapT and human DTWD1/2 as tRNA aminocarboxypropyltransferases responsible for acp3U formation. Inhibition of acp3U modification results in genome instability in heat-stressed E. coli and growth defects in human cells.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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