Influence of Slavinorm on Resuscitation of Rats Cardiorespiratory Functions under Deep Hypothermia

Abstract

The problem of resuscitating a man whose respiration and heart were arrested under strong cooling is urgent for the reanimation practice. The aim of this work was to study the influence of Slavinorm (a polypeptide complex of the vessels) on the heart work activation and the regeneration of their inherent respiration in the Wistar rats with the help of artificial ventilation of lungs (ALV) and warming the sternum region under deep hypothermia. The animals narcotized with urethan were cooled in water (9,2±0,5ºС) up to the arrest of respiration. The experimental group of rats 1 h before cooling were injected intraperitoneally with Slavinorm (15,6 mg/kg of weight) and the control rats were injected with physiological solution. In control rats the arrest of respiration was observed at the rectal temperature (Тr) 16,0±0,3ºС, in the esophagus (Te) 19,1±0,3ºС. The artificial lung ventilation (ALV) and heating the breast region resulted in the initiation of natural respiration in 29,2±0,4 min from the beginning of ALV at Tr 13,8±0,2ºС, Тe 16,1±0,2ºС. The conclusion: Slavinorm increases the resistance of an organism to cold, assists the prolongation of the process of cooling up to the arrest of respiration, decreases the temperature thresholds of the heart activation and resuscitation of natural respiration.

Keywords

• hypothermia
• respiration
• rats
• heart
• slavinorm – polypeptide vessel complex