Strength of Neisseria meningitidis binding to endothelial cells requires highly-ordered CD147/β2-adrenoceptor clusters assembled by alpha-actinin-4

Nawal Maïssa; Valentina Covarelli; Sébastien Janel; Beatrice Durel; Nandi Simpson; Sandra C. Bernard; Liliana Pardo-Lopez; Haniaa Bouzinba-Ségard; Camille Faure; Mark G.H. Scott; Mathieu Coureuil; Philippe C. Morand; Frank Lafont; Xavier Nassif; Stefano Marullo; Sandrine Bourdoulous

doi:10.1038/ncomms15764

Nature Communications (Jun 2017)

Strength of Neisseria meningitidis binding to endothelial cells requires highly-ordered CD147/β2-adrenoceptor clusters assembled by alpha-actinin-4

Nawal Maïssa,
Valentina Covarelli,
Sébastien Janel,
Beatrice Durel,
Nandi Simpson,
Sandra C. Bernard,
Liliana Pardo-Lopez,
Haniaa Bouzinba-Ségard,
Camille Faure,
Mark G.H. Scott,
Mathieu Coureuil,
Philippe C. Morand,
Frank Lafont,
Xavier Nassif,
Stefano Marullo,
Sandrine Bourdoulous

Affiliations

Nawal Maïssa: Department of Infection, Inserm, U1016, Immunity and Inflammation, Institut Cochin
Valentina Covarelli: Department of Infection, Inserm, U1016, Immunity and Inflammation, Institut Cochin
Sébastien Janel: Cellular Microbiology and Physics of infection, Center for Infection and Immunity of Lille, Institut Pasteur de Lille
Beatrice Durel: Department of Infection, Inserm, U1016, Immunity and Inflammation, Institut Cochin
Nandi Simpson: Department of Infection, Inserm, U1016, Immunity and Inflammation, Institut Cochin
Sandra C. Bernard: Department of Infection, Inserm, U1016, Immunity and Inflammation, Institut Cochin
Liliana Pardo-Lopez: Department of Infection, Inserm, U1016, Immunity and Inflammation, Institut Cochin
Haniaa Bouzinba-Ségard: Department of Infection, Inserm, U1016, Immunity and Inflammation, Institut Cochin
Camille Faure: Department of Infection, Inserm, U1016, Immunity and Inflammation, Institut Cochin
Mark G.H. Scott: Department of Infection, Inserm, U1016, Immunity and Inflammation, Institut Cochin
Mathieu Coureuil: Inserm, unité U1151, Institut-Necker-Enfants-Malades
Philippe C. Morand: Department of Infection, Inserm, U1016, Immunity and Inflammation, Institut Cochin
Frank Lafont: Cellular Microbiology and Physics of infection, Center for Infection and Immunity of Lille, Institut Pasteur de Lille
Xavier Nassif: Inserm, unité U1151, Institut-Necker-Enfants-Malades
Stefano Marullo: Department of Infection, Inserm, U1016, Immunity and Inflammation, Institut Cochin
Sandrine Bourdoulous: Department of Infection, Inserm, U1016, Immunity and Inflammation, Institut Cochin

DOI: https://doi.org/10.1038/ncomms15764
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 15

Abstract

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Neisseria meningitidis bacteria bind to host proteins CD147 and β2-adrenergic receptor on the surface of endothelial cells. Here, Maïssa et al. show that the two proteins interact with each other forming clusters that increase the binding strength of the bacteria to endothelial cells.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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