PLoS ONE (Jan 2019)

A prospective study of the immune reconstitution inflammatory syndrome (IRIS) in HIV-infected children from high prevalence countries.

  • Mark F Cotton,
  • Helena Rabie,
  • Elisa Nemes,
  • Hilda Mujuru,
  • Raziya Bobat,
  • Boniface Njau,
  • Avy Violari,
  • Vidya Mave,
  • Charles Mitchell,
  • James Oleske,
  • Bonnie Zimmer,
  • George Varghese,
  • Savita Pahwa,
  • P1073 team

DOI
https://doi.org/10.1371/journal.pone.0211155
Journal volume & issue
Vol. 14, no. 7
p. e0211155

Abstract

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BackgroundThe immune reconstitution inflammatory syndrome (IRIS) in HIV-infected infants and young children is relatively understudied in regions endemic for HIV and TB. We aimed to describe incidence, clinical features and risk factors of pediatric IRIS in Sub-Saharan Africa and India.Methods and findingsWe conducted an observational multi-centred prospective clinical study from December 2010 to September 2013 in children ConclusionsIRIS occurs commonly in HIV-infected children initiating ART and occasionally has severe morbidity. The incidence may be underestimated. Predictive, diagnostic and prognostic biomarkers are needed.