Diagnostic Performance of Quadruple Phase Multidetector Row Computed Tomography in Hepatoma: Comparison with Histopathological Diagnosis

Abstract

Objective: To determine diagnostic accuracy of quadruple phase helical computed tomography scan in detection of hepatocellular carcinoma in individuals with hepatitis B and C, keeping histopathology as the gold standard. Methods: A cross-sectional study was performed in the Radiology and Imaging department of a tertiary care university hospital during 2014 to 2016. All serologically positive patients were included. Quadruple phase computed tomography scan was done and results were interrelated with histological diagnosis. Results: Hepatocellular carcinoma was accurately diagnosed in 76 out of 80 patients using Quadruple phase computed tomography scan (sensitivity, 95%). It was correctly excluded in 70 of 72 patients (specificity, 97.2%). The overall diagnostic accuracy of Quadruple phase computed tomography scan for diagnosing hepatocellular carcinoma was 96.05%. The positive and negative predictive values were 97.4% and 94.59% respectively. Conclusion: Quadruple phase computed tomography is more effective in evaluating hepatocellular carcinoma than conventional biphasic and triphasic computed tomography scans. We propose it as the technique of first preference for imaging workup in patients with Hepatitis B and C.

Keywords

• hepatocellular carcinoma
• computed tomography
• diagnostic accuracy