Artery Research (Nov 2015)

P8.10 EFFECTS OF BARIATRIC SURGERY ON ENDOTHELIAL FUNCTION IN EXTREMELY OBESE PATIENTS

  • Anna Dzieża-Grudnik*,
  • Anna Gαuszewska,
  • Krzysztof Rewiuk,
  • Aleksander Kwater,
  • Bartosz Zarzycki,
  • Maαgorzata Fedyk-Łukasik,
  • Barbara Gryglewska,
  • Tomasz Grodzicki

DOI
https://doi.org/10.1016/j.artres.2015.10.332
Journal volume & issue
Vol. 12

Abstract

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Introduction: Bariatric surgery in extremely obese patients has influence on metabolic variables and body weight however data about influence on flow-mediated dilatation (FMD) of brachial artery are inconsistent. The aim of the study was to assess the effect of bariatric surgery on endothelial function measured by flow-mediated dilatation. Material and methods: We examined 35 patients with extreme obesity who met the eligibility criteria and underwent bariatric surgery (sleeve gastrectomy or Roux-en-Y Bypass). Brachial flow-mediated dilatation was performed using linear-array transducer (GE Vivid 3, GE Healthcare Medical Diagnostics, Little Chalfont, UK). Results: Data from 35 patients (34% men; age: 45+/−10) were collected. BMI decreased form 47,5 +/− 6 kg/m2 before surgery to 35,5 +/−5kg/m2 six months after surgery. FMD after six months has significantly improved. Median flow mediated dilatation before intervention was 6,5% (IQR 2–10,7) and after operation 8,5% (IQR 6,2–16,8). Improvement in FMD was higher in patients who underwent by-pass surgery (median 142% (IQR: 85–453)) in comparison to sleeve gastrectomy intervention (median 118% (IQR 67–246) but no statistical significance was observed between two groups. Conclusions: Bariatric surgery resulted in significant improvement in endothelial function and may have potential impact on reduction of cardiovascular risk.