Nature Communications (Dec 2019)

Atlas of quantitative single-base-resolution N 6-methyl-adenine methylomes

  • Casslynn W. Q. Koh,
  • Yeek Teck Goh,
  • W. S. Sho Goh

DOI
https://doi.org/10.1038/s41467-019-13561-z
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 15

Abstract

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N 6-methyladenosine (m6A) and N 6,2′-O-dimethyladenosine (m6Am) are eukaryotic mRNA modifications. Here the authors develop m6A-Crosslinking-Exonuclease-sequencing to map quantitative methylome changes at single-base-resolution after individually knocking out each known methyltransferase or demethylase.