Journal of Extracellular Vesicles (May 2015)
Biological properties of extracellular vesicles and their physiological functions
- María Yáñez-Mó,
- Pia R.-M. Siljander,
- Zoraida Andreu,
- Apolonija Bedina Zavec,
- Francesc E. Borràs,
- Edit I. Buzas,
- Krisztina Buzas,
- Enriqueta Casal,
- Francesco Cappello,
- Joana Carvalho,
- Eva Colás,
- Anabela Cordeiro-da Silva,
- Stefano Fais,
- Juan M. Falcon-Perez,
- Irene M. Ghobrial,
- Bernd Giebel,
- Mario Gimona,
- Michael Graner,
- Ihsan Gursel,
- Mayda Gursel,
- Niels H. H. Heegaard,
- An Hendrix,
- Peter Kierulf,
- Katsutoshi Kokubun,
- Maja Kosanovic,
- Veronika Kralj-Iglic,
- Eva-Maria Krämer-Albers,
- Saara Laitinen,
- Cecilia Lässer,
- Thomas Lener,
- Erzsébet Ligeti,
- Aija Linē,
- Georg Lipps,
- Alicia Llorente,
- Jan Lötvall,
- Mateja Manček-Keber,
- Antonio Marcilla,
- Maria Mittelbrunn,
- Irina Nazarenko,
- Esther N.M. Nolte-‘t Hoen,
- Tuula A. Nyman,
- Lorraine O'Driscoll,
- Mireia Olivan,
- Carla Oliveira,
- Éva Pállinger,
- Hernando A. del Portillo,
- Jaume Reventós,
- Marina Rigau,
- Eva Rohde,
- Marei Sammar,
- Francisco Sánchez-Madrid,
- N. Santarém,
- Katharina Schallmoser,
- Marie Stampe Ostenfeld,
- Willem Stoorvogel,
- Roman Stukelj,
- Susanne G. Van der Grein,
- M. Helena Vasconcelos,
- Marca H. M. Wauben,
- Olivier De Wever
Affiliations
- María Yáñez-Mó
- Unidad de Investigación, Hospital Sta Cristina, Instituto de Investigaciones Sanitarias Princesa (IIS-IP), Madrid, Spain
- Pia R.-M. Siljander
- Extracellular Vesicle Research, Division of Biochemistry and Biotechnology, Department of Biosciences, University of Helsinki, Helsinki, Finland
- Zoraida Andreu
- Unidad de Investigación, Hospital Sta Cristina, Instituto de Investigaciones Sanitarias Princesa (IIS-IP), Madrid, Spain
- Apolonija Bedina Zavec
- Laboratory for Molecular Biology and Nanobiotechnology, National Institute of Chemistry, Ljubljana, Slovenia
- Francesc E. Borràs
- IVECAT Group – “Germans Trias i Pujol” Research Institute, Badalona, Spain
- Edit I. Buzas
- Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary
- Krisztina Buzas
- Biological Research Centre, Hungarian Academy of Sciences, Szeged, Hungary
- Enriqueta Casal
- Unidad de Investigación, Hospital Sta Cristina, Instituto de Investigaciones Sanitarias Princesa (IIS-IP), Madrid, Spain
- Francesco Cappello
- Department of Experimental Biomedicine and Clinical Neuroscience, Human Anatomy Section, University of Palermo, Palermo, Italy
- Joana Carvalho
- Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal
- Eva Colás
- Research Unit in Biomedicine and Translational Oncology, Vall Hebron Institute of Research and Autonomous University of Barcelona, Barcelona, Spain
- Anabela Cordeiro-da Silva
- Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal
- Stefano Fais
- Anti-Tumour Drugs Section, Department of Therapeutic Research and Medicines Evaluation, National Institute of Health (ISS), Rome, Italy
- Juan M. Falcon-Perez
- Metabolomics Unit, CIC bioGUNE, CIBERehd, Bizkaia Technology Park, Derio, Spain
- Irene M. Ghobrial
- Dana-Farber Cancer Institute, Boston, MA, USA
- Bernd Giebel
- Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
- Mario Gimona
- Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University (PMU), Salzburg, Austria
- Michael Graner
- Department of Neurosurgery, University of Colorado Denver, CO, USA
- Ihsan Gursel
- Department of Molecular Biology and Genetics, Thorlab-Therapeutic Oligonucleotide Research Lab, Bilkent University, Ankara, Turkey
- Mayda Gursel
- Department of Biological Sciences, Middle East Technical University, Ankara, Turkey
- Niels H. H. Heegaard
- Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, University of Southern Denmark, Odense, Denmark
- An Hendrix
- Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium
- Peter Kierulf
- Bood Cell Research Group, Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway
- Katsutoshi Kokubun
- Dana-Farber Cancer Institute, Boston, MA, USA
- Maja Kosanovic
- Department of Immunochemistry and Glycobiology, Institute for the Application of Nuclear Energy, INEP, University of Belgrade, Belgrade, Serbia
- Veronika Kralj-Iglic
- Laboratory of Clinical Biophysics, Faculty of Health Sciences, University of Ljubljana, Ljubljana, Slovenia
- Eva-Maria Krämer-Albers
- Molecular Cell Biology and Focus Program Translational Neurosciences, University of Mainz, Mainz, Germany
- Saara Laitinen
- Research and Cell Services, Finnish Red Cross Blood Service, Helsinki, Finland
- Cecilia Lässer
- Krefting Research Centre, Institute of Medicine at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
- Thomas Lener
- Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University (PMU), Salzburg, Austria
- Erzsébet Ligeti
- Department of Physiology, Semmelweis University, Budapest, Hungary
- Aija Linē
- Latvian Biomedical Research and Study Centre, Riga, Latvia
- Georg Lipps
- Institute of Chemistry and Bioanalytics, School of Life Sciences, University of Applied Sciences and Arts Northwestern Switzerland, Muttenz, Switzerland
- Alicia Llorente
- Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital – The Norwegian Radium Hospital, Oslo, Norway
- Jan Lötvall
- Krefting Research Centre, Institute of Medicine at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
- Mateja Manček-Keber
- National Institute of Chemistry, Laboratory of Biotechnology, Ljubljana, Slovenia
- Antonio Marcilla
- Departamento de Biología Celular y Parasitologia, Facultat de Farmacia, Universitat de Valencia, Valencia, Spain
- Maria Mittelbrunn
- Department of Vascular Biology and Inflammation, Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain
- Irina Nazarenko
- Institute for Environmental Health Sciences and Hospital Infection ControlMedical Center – University of Freiburg, Freiburg im Breisgau, Germany
- Esther N.M. Nolte-‘t Hoen
- Department of Biochemistry and Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
- Tuula A. Nyman
- Institute of Biotechnology, (Viikinkaari 1), University of Helsinki, Helsinki, Finland
- Lorraine O'Driscoll
- School of Pharmacy and Pharmaceutical Sciences & Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland
- Mireia Olivan
- Research Unit in Biomedicine and Translational Oncology, Vall Hebron Institute of Research and Autonomous University of Barcelona, Barcelona, Spain
- Carla Oliveira
- Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal
- Éva Pállinger
- Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary
- Hernando A. del Portillo
- ISGlobal, Barcelona Ctr. Int. Health Res. (CRESIB), Hospital Clínic – Universitat de Barcelona, Barcelona, Spain
- Jaume Reventós
- Research Unit in Biomedicine and Translational Oncology, Vall Hebron Institute of Research and Autonomous University of Barcelona, Barcelona, Spain
- Marina Rigau
- Research Unit in Biomedicine and Translational Oncology, Vall Hebron Institute of Research and Autonomous University of Barcelona, Barcelona, Spain
- Eva Rohde
- Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University (PMU), Salzburg, Austria
- Marei Sammar
- Department of Biotechnology Engineering, ORT Braude College, Karmiel, Israel
- Francisco Sánchez-Madrid
- Department of Vascular Biology and Inflammation, Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain
- N. Santarém
- Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal
- Katharina Schallmoser
- Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University (PMU), Salzburg, Austria
- Marie Stampe Ostenfeld
- Departmnet of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark
- Willem Stoorvogel
- Department of Biochemistry and Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
- Roman Stukelj
- Laboratory of Clinical Biophysics, Faculty of Health Sciences, University of Ljubljana, Ljubljana, Slovenia
- Susanne G. Van der Grein
- Department of Biochemistry and Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
- M. Helena Vasconcelos
- Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal
- Marca H. M. Wauben
- Department of Biochemistry and Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
- Olivier De Wever
- Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium
- DOI
- https://doi.org/10.3402/jev.v4.27066
- Journal volume & issue
-
Vol. 4,
no. 0
pp. 1 – 60
Abstract
In the past decade, extracellular vesicles (EVs) have been recognized as potent vehicles of intercellular communication, both in prokaryotes and eukaryotes. This is due to their capacity to transfer proteins, lipids and nucleic acids, thereby influencing various physiological and pathological functions of both recipient and parent cells. While intensive investigation has targeted the role of EVs in different pathological processes, for example, in cancer and autoimmune diseases, the EV-mediated maintenance of homeostasis and the regulation of physiological functions have remained less explored. Here, we provide a comprehensive overview of the current understanding of the physiological roles of EVs, which has been written by crowd-sourcing, drawing on the unique EV expertise of academia-based scientists, clinicians and industry based in 27 European countries, the United States and Australia. This review is intended to be of relevance to both researchers already working on EV biology and to newcomers who will encounter this universal cell biological system. Therefore, here we address the molecular contents and functions of EVs in various tissues and body fluids from cell systems to organs. We also review the physiological mechanisms of EVs in bacteria, lower eukaryotes and plants to highlight the functional uniformity of this emerging communication system.
Keywords
