Nature Communications (Oct 2018)
Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1
- Salima Daou,
- Haithem Barbour,
- Oumaima Ahmed,
- Louis Masclef,
- Caroline Baril,
- Nadine Sen Nkwe,
- Daméhan Tchelougou,
- Maxime Uriarte,
- Eric Bonneil,
- Derek Ceccarelli,
- Nazar Mashtalir,
- Mika Tanji,
- Jean-Yves Masson,
- Pierre Thibault,
- Frank Sicheri,
- Haining Yang,
- Michele Carbone,
- Marc Therrien,
- El Bachir Affar
Affiliations
- Salima Daou
- Maisonneuve-Rosemont Hospital Research Center and Department of Medicine, University of Montréal
- Haithem Barbour
- Maisonneuve-Rosemont Hospital Research Center and Department of Medicine, University of Montréal
- Oumaima Ahmed
- Maisonneuve-Rosemont Hospital Research Center and Department of Medicine, University of Montréal
- Louis Masclef
- Maisonneuve-Rosemont Hospital Research Center and Department of Medicine, University of Montréal
- Caroline Baril
- Institute for Research in Immunology and Cancer, Laboratory of Intracellular Signaling, University of Montréal
- Nadine Sen Nkwe
- Maisonneuve-Rosemont Hospital Research Center and Department of Medicine, University of Montréal
- Daméhan Tchelougou
- Maisonneuve-Rosemont Hospital Research Center and Department of Medicine, University of Montréal
- Maxime Uriarte
- Maisonneuve-Rosemont Hospital Research Center and Department of Medicine, University of Montréal
- Eric Bonneil
- Institute for Research in Immunology and Cancer, Laboratory of Proteomics and Bioanalytical Mass Spectrometry, University of Montréal
- Derek Ceccarelli
- Lunenfeld-Tanenbaum Research Institute, Sinai Health System
- Nazar Mashtalir
- Maisonneuve-Rosemont Hospital Research Center and Department of Medicine, University of Montréal
- Mika Tanji
- University of Hawaii Cancer Center, University of Hawaii
- Jean-Yves Masson
- CHU de Quebec Research Center (Oncology Axis), Laval University Cancer Research Center, 9 McMahon
- Pierre Thibault
- Institute for Research in Immunology and Cancer, Laboratory of Proteomics and Bioanalytical Mass Spectrometry, University of Montréal
- Frank Sicheri
- Lunenfeld-Tanenbaum Research Institute, Sinai Health System
- Haining Yang
- University of Hawaii Cancer Center, University of Hawaii
- Michele Carbone
- University of Hawaii Cancer Center, University of Hawaii
- Marc Therrien
- Institute for Research in Immunology and Cancer, Laboratory of Intracellular Signaling, University of Montréal
- El Bachir Affar
- Maisonneuve-Rosemont Hospital Research Center and Department of Medicine, University of Montréal
- DOI
- https://doi.org/10.1038/s41467-018-06854-2
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 21
Abstract
Additional sex combs-like (ASXLs) stimulate BAP1 deubiquitinase activity to induce tumor suppression, but how these complexes work in coordination in vivo is unclear. Here, the authors show the mutually reinforcing roles of BAP1 and ASXLs such that BAP1 promotes DEUBAD monoubiquitination of ASXL2, which in turn stimulates BAP1 DUB activity.
