Association of hypoxic burden metrics with cardiovascular outcomes in heart failure and sleep‐disordered breathing

Abstract

Abstract Aims Heart failure (HF) and sleep‐disordered breathing (SDB) frequently coexist. We aimed to compare the prognostic value of different nocturnal hypoxic burden metrics in hospitalized HF patients. Methods and results HF patients underwent polygraphy screening for SDB in this prospective cohort. Hypoxic burden metrics assessed using pulse oximetry included time 52.0 min (HR 1.56, 95% CI: 1.21–2.02, P = 0.001) had a greater risk of the composite outcome than those with T90 95%, meanSO2 < 93% (HR 1.47, 95% CI: 1.16–1.88, P = 0.002) was correlated with adverse outcomes. Conclusions The hypoxic burden metrics T90, TRT90, and meanSO2, but not ODI, were independent predictors of cardiovascular death or readmission for worsening HF. Indicators of duration and severity, not just the frequency of nocturnal hypoxaemia, should be valued and considered for intervention to improve outcomes in HF patients.

Keywords

• Heart failure
• Sleep‐disordered breathing
• Cardiovascular
• Outcome
• Sleep apnoea