Reproductive disorders in the experimental modeling of tuberculosis

Abstract

For experimental modeling of tuberculosis, animals of various species are used, each of which has its own advantages and disadvantages. Specific characteristics of animal genetics and immunology during the development of tuberculosis in the experiment were studied in sufficient detail. In addition, mice, guinea pigs, and primates are widely used to test new vaccines and candidate drugs. Modeling of tuberculosis of reproductive organs of females has been developed much worse, since artificial approaches to reproducing genital tuberculosis which do not correspond to the real development of pathology in humans, are more often used. The review describes aspects of modeling tuberculosis as systemic and local infectious process including the study of disorders in the reproductive system of female animals during the development of pulmonary tuberculosis.

Keywords

• m. tuberculosis
• туберкулез
• экспериментальные животные
• воспаление
• микробиота