Analgesic activity of the salts of 2-(5-(adamantane-1-yl)-4-R-1,2,4-triazole-3-ylthio)acetic acid

Abstract

Despite the varied approaches to the pain syndrome therapy with the changes and improvements of evolutionary medicine’s development and the drugs which are used to treat pain there are still considerable difficulties in solving this problem. Aim. To detect compounds that are able to change the pain in experimental animals the action of salts of 2-(5-(adamantane-1-yl)-4-R-1,2,4-triazole-3-ylthio)acetic acid on central component of the nociceptive system has been studied in terms of thermal irritation of the extremities of rats. Materials and results. First synthesized salts of 2-(5-(adamantane-1-yl)-4-R-1,2,4-triazole-3- ylthio)acetic acid have been used in studies. Analgesic activity has been determined on «a hot plate» model, based on the ability of studied substances to change the pain threshold of experimental animals in comparison with control and expressed in percents. Analgin was used as the comparison drug at a dose of 1000 mg/kg (Analgin-Darnitsa, solution for injections, 500 mg/ml, 2 ml in ampules № 10). Conclusions. The regularities between chemical structure and pharmacological action of 1,2,4-triazole derivatives have been determined. It testifies the prospects of further studies of salts of 2-(5-(adamantane-1-yl)-4-R-1,2,4-triazole-3-ylthio)acetic acid, as potential substances to create new drugs.

Keywords

• Analgesics
• Adamantane
• 1 2 4-triazole