Nature Communications (Mar 2016)
The TLX-miR-219 cascade regulates neural stem cell proliferation in neurodevelopment and schizophrenia iPSC model
- Kiyohito Murai,
- Guoqiang Sun,
- Peng Ye,
- E. Tian,
- Su Yang,
- Qi Cui,
- Guihua Sun,
- Daniel Trinh,
- Olivia Sun,
- Teresa Hong,
- Zhexing Wen,
- Markus Kalkum,
- Arthur D. Riggs,
- Hongjun Song,
- Guo-li Ming,
- Yanhong Shi
Affiliations
- Kiyohito Murai
- Division of Stem Cell Biology Research, Department of Developmental and Stem Cell Biology, Cancer Center, Beckman Research Institute of City of Hope
- Guoqiang Sun
- Division of Stem Cell Biology Research, Department of Developmental and Stem Cell Biology, Cancer Center, Beckman Research Institute of City of Hope
- Peng Ye
- Division of Stem Cell Biology Research, Department of Developmental and Stem Cell Biology, Cancer Center, Beckman Research Institute of City of Hope
- E. Tian
- Division of Stem Cell Biology Research, Department of Developmental and Stem Cell Biology, Cancer Center, Beckman Research Institute of City of Hope
- Su Yang
- Division of Stem Cell Biology Research, Department of Developmental and Stem Cell Biology, Cancer Center, Beckman Research Institute of City of Hope
- Qi Cui
- Division of Stem Cell Biology Research, Department of Developmental and Stem Cell Biology, Cancer Center, Beckman Research Institute of City of Hope
- Guihua Sun
- Department of Diabetes and Metabolic Diseases Research, Beckman Research Institute of City of Hope
- Daniel Trinh
- Division of Stem Cell Biology Research, Department of Developmental and Stem Cell Biology, Cancer Center, Beckman Research Institute of City of Hope
- Olivia Sun
- Division of Stem Cell Biology Research, Department of Developmental and Stem Cell Biology, Cancer Center, Beckman Research Institute of City of Hope
- Teresa Hong
- Department of Molecular Immunology, Beckman Research Institute of City of Hope
- Zhexing Wen
- Institute for Cell Engineering, Johns Hopkins University School of Medicine
- Markus Kalkum
- Department of Molecular Immunology, Beckman Research Institute of City of Hope
- Arthur D. Riggs
- Department of Diabetes and Metabolic Diseases Research, Beckman Research Institute of City of Hope
- Hongjun Song
- Institute for Cell Engineering, Johns Hopkins University School of Medicine
- Guo-li Ming
- Institute for Cell Engineering, Johns Hopkins University School of Medicine
- Yanhong Shi
- Division of Stem Cell Biology Research, Department of Developmental and Stem Cell Biology, Cancer Center, Beckman Research Institute of City of Hope
- DOI
- https://doi.org/10.1038/ncomms10965
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 15
Abstract
Dysregulation of microRNAs has been implicated in neurodevelopmental disorders, including schizophrenia. Here the authors show that the TLX-miR-219 cascade regulates the proliferation of neural stem cells during normal development, and this pathway is dysregulated in a schizophrenia iPSC model.
