Nature Communications (May 2017)

The comparative immunology of wild and laboratory mice, Mus musculus domesticus

  • Stephen Abolins,
  • Elizabeth C. King,
  • Luke Lazarou,
  • Laura Weldon,
  • Louise Hughes,
  • Paul Drescher,
  • John G. Raynes,
  • Julius C. R. Hafalla,
  • Mark E. Viney,
  • Eleanor M. Riley

DOI
https://doi.org/10.1038/ncomms14811
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 13

Abstract

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Laboratory mice are the cornerstone of immunology but how well they represent wild mice is not clear. Here the authors compare and contrast various immune parameters between wild-caught mice and laboratory (C57BL/6) mice and identify a previously unknown myeloid cell population specific to wild mice.