Nature Communications (Feb 2016)
The REGγ-proteasome forms a regulatory circuit with IκBɛ and NFκB in experimental colitis
- Jinjin Xu,
- Lei Zhou,
- Lei Ji,
- Fengyuan Chen,
- Karen Fortmann,
- Kun Zhang,
- Qingwu Liu,
- Ke Li,
- Weicang Wang,
- Hao Wang,
- Wei Xie,
- Qingwei Wang,
- Jiang Liu,
- Biao Zheng,
- Pei Zhang,
- Shixia Huang,
- Tieliu Shi,
- Biaohong Zhang,
- Yongyan Dang,
- Jiwu Chen,
- Bert W. O’Malley,
- Robb E. Moses,
- Ping Wang,
- Lei Li,
- Jianru Xiao,
- Alexander Hoffmann,
- Xiaotao Li
Affiliations
- Jinjin Xu
- Shanghai Key Laboratory of Regulatory Biology, Shanghai Key Laboratory of Brain Functional Genomics (Ministry of Education), Institute of Biomedical Sciences, East China Normal University
- Lei Zhou
- Shanghai Key Laboratory of Regulatory Biology, Shanghai Key Laboratory of Brain Functional Genomics (Ministry of Education), Institute of Biomedical Sciences, East China Normal University
- Lei Ji
- Shanghai Key Laboratory of Regulatory Biology, Shanghai Key Laboratory of Brain Functional Genomics (Ministry of Education), Institute of Biomedical Sciences, East China Normal University
- Fengyuan Chen
- The Fifth Hospital of Shanghai, Fudan University
- Karen Fortmann
- Signaling Systems Laboratory and San Diego Center for Systems Biology, University of California
- Kun Zhang
- Shanghai Key Laboratory of Regulatory Biology, Shanghai Key Laboratory of Brain Functional Genomics (Ministry of Education), Institute of Biomedical Sciences, East China Normal University
- Qingwu Liu
- Shanghai Key Laboratory of Regulatory Biology, Shanghai Key Laboratory of Brain Functional Genomics (Ministry of Education), Institute of Biomedical Sciences, East China Normal University
- Ke Li
- Shanghai Key Laboratory of Regulatory Biology, Shanghai Key Laboratory of Brain Functional Genomics (Ministry of Education), Institute of Biomedical Sciences, East China Normal University
- Weicang Wang
- Shanghai Key Laboratory of Regulatory Biology, Shanghai Key Laboratory of Brain Functional Genomics (Ministry of Education), Institute of Biomedical Sciences, East China Normal University
- Hao Wang
- Shanghai Key Laboratory of Regulatory Biology, Shanghai Key Laboratory of Brain Functional Genomics (Ministry of Education), Institute of Biomedical Sciences, East China Normal University
- Wei Xie
- Shanghai Key Laboratory of Regulatory Biology, Shanghai Key Laboratory of Brain Functional Genomics (Ministry of Education), Institute of Biomedical Sciences, East China Normal University
- Qingwei Wang
- Shanghai Key Laboratory of Regulatory Biology, Shanghai Key Laboratory of Brain Functional Genomics (Ministry of Education), Institute of Biomedical Sciences, East China Normal University
- Jiang Liu
- The Institute of Aging Research, School of Medicine, Hangzhou Normal University
- Biao Zheng
- Shanghai Key Laboratory of Regulatory Biology, Shanghai Key Laboratory of Brain Functional Genomics (Ministry of Education), Institute of Biomedical Sciences, East China Normal University
- Pei Zhang
- Department of Pathology, the Second Chengdu Municipal Hospital
- Shixia Huang
- Department of Molecular and Cellular Biology, The Dan L. Duncan Cancer Center, Baylor College of Medicine. One Baylor Plaza
- Tieliu Shi
- Shanghai Key Laboratory of Regulatory Biology, Shanghai Key Laboratory of Brain Functional Genomics (Ministry of Education), Institute of Biomedical Sciences, East China Normal University
- Biaohong Zhang
- Shanghai Key Laboratory of Regulatory Biology, Shanghai Key Laboratory of Brain Functional Genomics (Ministry of Education), Institute of Biomedical Sciences, East China Normal University
- Yongyan Dang
- Shanghai Key Laboratory of Regulatory Biology, Shanghai Key Laboratory of Brain Functional Genomics (Ministry of Education), Institute of Biomedical Sciences, East China Normal University
- Jiwu Chen
- Shanghai Key Laboratory of Regulatory Biology, Shanghai Key Laboratory of Brain Functional Genomics (Ministry of Education), Institute of Biomedical Sciences, East China Normal University
- Bert W. O’Malley
- Department of Molecular and Cellular Biology, The Dan L. Duncan Cancer Center, Baylor College of Medicine. One Baylor Plaza
- Robb E. Moses
- Department of Molecular and Cellular Biology, The Dan L. Duncan Cancer Center, Baylor College of Medicine. One Baylor Plaza
- Ping Wang
- Shanghai Key Laboratory of Regulatory Biology, Shanghai Key Laboratory of Brain Functional Genomics (Ministry of Education), Institute of Biomedical Sciences, East China Normal University
- Lei Li
- Shanghai Key Laboratory of Regulatory Biology, Shanghai Key Laboratory of Brain Functional Genomics (Ministry of Education), Institute of Biomedical Sciences, East China Normal University
- Jianru Xiao
- Department of Orthopedic Oncology, Changzheng Hospital, The Second Military Medical University
- Alexander Hoffmann
- Signaling Systems Laboratory and San Diego Center for Systems Biology, University of California
- Xiaotao Li
- Shanghai Key Laboratory of Regulatory Biology, Shanghai Key Laboratory of Brain Functional Genomics (Ministry of Education), Institute of Biomedical Sciences, East China Normal University
- DOI
- https://doi.org/10.1038/ncomms10761
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 14
Abstract
REGγ is a component of ubiquitin-independent 20S proteasome that targets many regulatory proteins for degradation. Here the authors show that REGγ is induced in DSS colitis and promotes degradation of IκBɛ, and that REGγ-deficient mice have less NFκB activation and are more resistant to the disease.
