mSphere
(Aug 2021)
A Toxic Friend: Genotoxic and Mutagenic Activity of the Probiotic Strain Escherichia coli Nissle 1917
Jean-Philippe Nougayrède,
Camille V. Chagneau,
Jean-Paul Motta,
Nadège Bossuet-Greif,
Marcy Belloy,
Frédéric Taieb,
Jean-Jacques Gratadoux,
Muriel Thomas,
Philippe Langella,
Eric Oswald
Affiliations
Jean-Philippe Nougayrède
ORCiD IRSD, INSERM, INRAE, Université de Toulouse, ENVT, Toulouse, France
Camille V. Chagneau
ORCiD IRSD, INSERM, INRAE, Université de Toulouse, ENVT, Toulouse, France
Jean-Paul Motta
ORCiD IRSD, INSERM, INRAE, Université de Toulouse, ENVT, Toulouse, France
Nadège Bossuet-Greif
IRSD, INSERM, INRAE, Université de Toulouse, ENVT, Toulouse, France
Marcy Belloy
IRSD, INSERM, INRAE, Université de Toulouse, ENVT, Toulouse, France
Frédéric Taieb
IRSD, INSERM, INRAE, Université de Toulouse, ENVT, Toulouse, France
Jean-Jacques Gratadoux
Micalis, INRAE, Jouy-en-Josas, France
Muriel Thomas
Micalis, INRAE, Jouy-en-Josas, France
Philippe Langella
Micalis, INRAE, Jouy-en-Josas, France
Eric Oswald
ORCiD IRSD, INSERM, INRAE, Université de Toulouse, ENVT, Toulouse, France
DOI
https://doi.org/10.1128/mSphere.00624-21
Journal volume & issue
Vol. 6,
no. 4
Abstract
Read online
Nissle 1917 is sold as a probiotic and considered safe even though it has been known since 2006 that it harbors the genes for colibactin synthesis. Colibactin is a potent genotoxin that is now linked to causative mutations found in human colorectal cancer.
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