New Derivatives of Lupeol and Their Biological Activity
Hoang-Thuy-Tien Le,
Quoc-Cuong Chau,
Thuc-Huy Duong,
Quyen-Thien-Phuc Tran,
Nguyen-Kim-Tuyen Pham,
Thi-Hoai-Thu Nguyen,
Ngoc-Hong Nguyen,
Jirapast Sichaem
Affiliations
Hoang-Thuy-Tien Le
Department of Organic Chemistry, Faculty of Chemistry, Ho Chi Minh City University of Education, Ho Chi Minh City 72711, Vietnam
Quoc-Cuong Chau
Department of Organic Chemistry, Faculty of Chemistry, Ho Chi Minh City University of Education, Ho Chi Minh City 72711, Vietnam
Thuc-Huy Duong
Department of Organic Chemistry, Faculty of Chemistry, Ho Chi Minh City University of Education, Ho Chi Minh City 72711, Vietnam
Quyen-Thien-Phuc Tran
Department of Organic Chemistry, Faculty of Chemistry, Ho Chi Minh City University of Education, Ho Chi Minh City 72711, Vietnam
Nguyen-Kim-Tuyen Pham
Faculty of Environmental Science, Sai Gon University, Ho Chi Minh City 72711, Vietnam
Thi-Hoai-Thu Nguyen
Faculty of Basic Sciences, University of Medicine and Pharmacy at Ho Chi Minh City, 217 Hong Bang Street, Dist. 5, Ho Chi Minh City 700000, Vietnam
Ngoc-Hong Nguyen
CirTech Institute, HUTECT University, Ho Chi Minh City 72324, Vietnam
Jirapast Sichaem
Research Unit in Natural Products Chemistry and Bioactivities, Faculty of Science and Technology, Thammasat University Lampang Campus, Lampang 52190, Thailand
The natural product lupeol (1) was isolated from Bombax ceiba leaves, which were used as starting material in the semisynthetic approach. Three new derivatives (2a, 2b, and 3) were synthesized using oxidation and aldolization. Their chemical structures were elucidated by spectroscopic analyses (HRESIMS and NMR). Compounds 3 showed significant α-glucosidase inhibition with an IC50 value of 202 µM, whereas 2a and 2b were inactive.
