Structural basis for the inactivation of cytosolic DNA sensing by the vaccinia virus

Angel Rivera-Calzada; Raquel Arribas-Bosacoma; Alba Ruiz-Ramos; Paloma Escudero-Bravo; Jasminka Boskovic; Rafael Fernandez-Leiro; Antony W. Oliver; Laurence H. Pearl; Oscar Llorca

doi:10.1038/s41467-022-34843-z

Nature Communications (Nov 2022)

Structural basis for the inactivation of cytosolic DNA sensing by the vaccinia virus

Angel Rivera-Calzada,
Raquel Arribas-Bosacoma,
Alba Ruiz-Ramos,
Paloma Escudero-Bravo,
Jasminka Boskovic,
Rafael Fernandez-Leiro,
Antony W. Oliver,
Laurence H. Pearl,
Oscar Llorca

Affiliations

Angel Rivera-Calzada: Spanish National Cancer Research Centre (CNIO)
Raquel Arribas-Bosacoma: Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Falmer
Alba Ruiz-Ramos: Spanish National Cancer Research Centre (CNIO)
Paloma Escudero-Bravo: Spanish National Cancer Research Centre (CNIO)
Jasminka Boskovic: Spanish National Cancer Research Centre (CNIO)
Rafael Fernandez-Leiro: Spanish National Cancer Research Centre (CNIO)
Antony W. Oliver: Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Falmer
Laurence H. Pearl: Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Falmer
Oscar Llorca: Spanish National Cancer Research Centre (CNIO)

DOI: https://doi.org/10.1038/s41467-022-34843-z
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 13

Abstract

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Vaccinia virus expresses two proteins that interfere with the host immune response. Here, authors provide the structural basis for this viral defence mechanism, conserved in other poxviruses such as the causatives agents of smallpox and monkeypox.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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