Chemotherapy-induced Takotsubo cardiomyopathy, a case report and review of the literature

Abstract

Abstract Background Several chemotherapy molecules, monoclonal antibodies and tyrosine kinase inhibitors, have been linked to Takotsubo cardiomyopathy (TC). Case presentation In this article, we describe the case of a 45-year-old woman who developed TC after receiving an intra-arterial and intra-venous polychemotherapy for locally advanced epidermoid carcinoma of the anal canal. This is the first described case of TC associated with intra-arterial chemotherapy. Conclusions A review of the literature points to 5-fluorouracil as the most common molecule associated with TC and highlights the potential risk associated with rechallenging patient with the same drug.

Keywords

• Takotsubo cardiomyopathy
• Chemotherapy
• Intra-arterial chemotherapy
• Rechallenge
• Case report