Sickle cell anemia and pregnancy: Profile of hemodynamic changes in sickle cell pregnant women in Kinshasa
Tite Minga Mikobi,
Nelly Ciombo Kamuanya,
Emmanuelle Ketsia Bokashanga Mikobi,
Thérèse Ilunga Kalela,
Pierre Zalagile Akilimali,
Prosper Tshilobo Lukusa
Affiliations
Tite Minga Mikobi
Centre d'Excellence de la Drépanocytose, Department of Molecular Biology and Genetics, Department of Basic Sciences, School of Medicine University of Kinshasa Kinshasa DRC
Nelly Ciombo Kamuanya
Centre d'Excellence de la Drépanocytose, Department of Molecular Biology and Genetics, Department of Basic Sciences, School of Medicine University of Kinshasa Kinshasa DRC
Emmanuelle Ketsia Bokashanga Mikobi
Centre d'Excellence de la Drépanocytose, Department of Molecular Biology and Genetics, Department of Basic Sciences, School of Medicine University of Kinshasa Kinshasa DRC
Thérèse Ilunga Kalela
Service of ecotoxicology, department of the environment, Faculty of sciences University of Kinshasa Kinshasa DRC
Pierre Zalagile Akilimali
Department of Epidemiology and Biostatistics, School of Public Health University of Kinshasa Kinshasa DRC
Prosper Tshilobo Lukusa
Centre d'Excellence de la Drépanocytose, Department of Molecular Biology and Genetics, Department of Basic Sciences, School of Medicine University of Kinshasa Kinshasa DRC
Abstract Pregnancy is accompanied by hormonal changes. These relate mainly to progesterone and placenate growth factor. Hemodynamic changes are also observed. in a sickle cell pregnant woman, all these changes have a direct effect on hypoxia. This is responsible for the polymerization of HbS. The latter causes the sickling of sickle red blood cells. sickling of red blood cells is responsible for hemolysis and vasoocclusion, two major acute manifestations during pregnancy in a sickle cell patient.
