Molecules (Jan 2005)

Synthesis of the Key Precursor of Hirsutellide A

  • Ligong Chen,
  • Yi Meng,
  • Guangle Zhao,
  • Liqin Jiang,
  • Meiling Li,
  • Xuemin Duan,
  • Yanjie Xu

DOI
https://doi.org/10.3390/10010259
Journal volume & issue
Vol. 10, no. 1
pp. 259 – 264

Abstract

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Hexadepsipeptide 2, the precursor of Hirsutellide A (1), was synthesized in an overall yield of 45% from N-Boc-Me-Gly via three coupling reactions using dicyclohexylcarbodiimide (DCC), O-(7-azabenzotriazol-1-yl)-N,N,N’,N’-tetramethyl- uronium hexafluorophosphate (HATU) and bis(2-oxo-3-oxazolidinyl)phosphinic chloride (BOP-Cl), respectively.

Keywords