Effect of hormone receptors and Her-2 status on metastasis status in patients with breast cancer using logistic regression model

Abstract

Introduction: Breast cancer is the most common type of cancer and the leading cause of cancer death among women. According to estimates in 2018, the most frequency of cancer in Iranian women was related to breast cancer with 13776 (12.5%) new cases. Metastasis is a complication of this disease that occurs in 1%-5% of patients. The aim of this study was to investigate the effect of hormone receptors and Her-2 status on metastasis status in patients with breast cancer using logistic regression. Materials and Methods: In this retrospective study, medical records of 165 breast cancer patients referred to the Ahvaz Shafa Diagnostic and Treatment Center who underwent surgery during 2006-2014 was recorded. Multinomial logistic regression model was applied to identify the related factors to the metastasis status. Results: In the studied patients, 35.2% (58 patients) experienced metastasis. In multinomial logistic model, Her-2 status (P = 0.026) and lymph node involvement (P <0.001) were significant. The odds of metastasis in ER-positive individuals was 2.24 times that of ER-negative individuals (AOR=2.24; CI95%: (0.955-5.275)). Also, the odds of metastasis in patients with lymph node involvement was 5.40 times that of patients without involvement (AOR=5.407; CI95%: (2.180-13.414)). This odds in people with Her-2-positive status was 2.35 times than in those with Her-2-negative status (AOR=0.438; CI95%: (1.109-4.999)). Conclusion: In this study, Her-2-positive status and lymph node involvement were identified as factors associated with metastasis. Early detection of these factors can lead to greater survival of breast cancer patients.

Keywords

• breast neoplasms
• neoplasm metastasis
• estrogen receptors
• progesterone receptors