Urinary 6-sulfatoxymelatonin level in girls and its relationship with obesity

Korean Journal of Pediatrics. 2012;55(9):344-349 DOI 10.3345/kjp.2012.55.9.344

 

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Journal Title: Korean Journal of Pediatrics

ISSN: 1738-1061 (Print); 2092-7258 (Online)

Publisher: Korean Pediatric Society

LCC Subject Category: Medicine: Pediatrics

Country of publisher: Korea, Republic of

Language of fulltext: English

Full-text formats available: PDF, HTML

 

AUTHORS

Jieun Lee (Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea.)
Juyoung Yoon (Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea.)
Jin A Lee (Department of Pediatrics, SMG-SNU Boramae Medical Center, Seoul, Korea.)
Seong Yong Lee (Department of Pediatrics, SMG-SNU Boramae Medical Center, Seoul, Korea.)
Choong Ho Shin (Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea.)
Sei Won Yang (Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea.)

EDITORIAL INFORMATION

Peer review

Editorial Board

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Time From Submission to Publication: 12 weeks

 

Abstract | Full Text

PurposeShort sleep duration is associated with obesity. Urinary 6-sulfatoxymelatonin (6-OHMS), the principal metabolite of melatonin, is closely related with sleep. We evaluated the difference in urinary 6-OHMS levels between obese girls and normal weight girls, and the relationship of urinary 6-OHMS with other hormones regulating body weight and metabolism.MethodsA total of 79 girls (6.3 to 12.4 years) were included in this study, of whom 34 were obese; 15, overweight; and 30, normal-weight. We examined their pubertal status and bone age. Fasting serum levels of total ghrelin, leptin, insulin, and first morning urinary 6-OHMS were measured. Homeostatic model assessment-insulin resistance (HOMA-IR) was calculated from the fasting insulin and glucose levels.ResultsThere was no significant difference in the creatinine adjusted 6-OHMS levels between the obese girls and the control group. Urinary 6-OHMS did not show any correlations with body mass index (BMI), BMI percentile, total ghrelin, leptin, and HOMA-IR. Negative correlations were found between urinary 6-OHMS levels and chronological and bone ages.ConclusionOur results suggest that melatonin production is not reduced consistently in obese girls.