Another string to the polo bow: a new mitotic role of PLK1 in centromere protection

Abstract

Polo-like kinase 1 (PLK1) plays a fundamental role in the spatiotemporal control of mitosis. Cells lacking PLK1 activity exhibit characteristic chromosome misalignment due to defects in microtubule-kinetochore organization and attachment. In our recently published paper, we uncover a new role for PLK1 in the preservation and maintenance of centromere integrity.

Keywords

• plk1
• chromosome biorientation
• centromere dislocation
• ultra-fine dna bridges
• blm helicase
• pich translocase