Nature Communications (Jan 2020)
Understanding the structural basis of HIV-1 restriction by the full length double-domain APOBEC3G
Abstract
APOBEC3G (A3G) belongs to the DNA/RNA cytosine deaminase family that plays important roles in innate immunity against HIV and internal retroelements. Here the authors report the structures of two full-length A3G variants that provides insight into domain organization, multimerization, RNA binding, and viral restriction.