Nature Communications (Jan 2020)

Understanding the structural basis of HIV-1 restriction by the full length double-domain APOBEC3G

  • Hanjing Yang,
  • Fumiaki Ito,
  • Aaron D. Wolfe,
  • Shuxing Li,
  • Nazanin Mohammadzadeh,
  • Robin P. Love,
  • Maocai Yan,
  • Brett Zirkle,
  • Amit Gaba,
  • Linda Chelico,
  • Xiaojiang S. Chen

DOI
https://doi.org/10.1038/s41467-020-14377-y
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 11

Abstract

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APOBEC3G (A3G) belongs to the DNA/RNA cytosine deaminase family that plays important roles in innate immunity against HIV and internal retroelements. Here the authors report the structures of two full-length A3G variants that provides insight into domain organization, multimerization, RNA binding, and viral restriction.