miR-29 as Indicator of Health and Disease in Sports Medicine - A Review

Abstract

Recent research is about the role of miR-29 accompanied by various conditions especially during the physical activity is a case of special attention, such as high intensity interval training (HIIT) and continuous aerobic training (CT) protective in heart, renal, lung, liver and even immune system adaptation. Since recent studies indicated the rolls of miR family on health and disease such as the effect of miR on health parameters evaluation and cardiovascular-respiratory, diabetic cardiomyopathy, diabetes, hypertension, myocardial infarction, gastric and breast cancer. Blocking harmful genes such as COL-1, CTGF, SMAD3, TGF-β, NFK-B and genes expression related to health such as miR-29 is a primary approach in treatment of some diseases. Meanwhile sports as HIIT and CT can be safe approach for genes expression related health and blocking harmful genes. This regulations applies by miRs especially miR-29 that is one mystery regulator in variety of diseases. We will give a brief account of relation between sports activities and miR-29 expression in this review.

Keywords

• miR-29
• Sports medicine
• Health
• Disease
• Gene regulation