Nature Communications (Apr 2023)
An epigenetic switch controls an alternative NR2F2 isoform that unleashes a metastatic program in melanoma
- Veronica Davalos,
- Claudia D. Lovell,
- Richard Von Itter,
- Igor Dolgalev,
- Praveen Agrawal,
- Gillian Baptiste,
- David J. Kahler,
- Elena Sokolova,
- Sebastian Moran,
- Laia Piqué,
- Eleazar Vega-Saenz de Miera,
- Barbara Fontanals-Cirera,
- Alcida Karz,
- Aristotelis Tsirigos,
- Chi Yun,
- Farbod Darvishian,
- Heather C. Etchevers,
- Iman Osman,
- Manel Esteller,
- Markus Schober,
- Eva Hernando
Affiliations
- Veronica Davalos
- Department of Pathology, New York University Grossman School of Medicine
- Claudia D. Lovell
- Department of Pathology, New York University Grossman School of Medicine
- Richard Von Itter
- Department of Pathology, New York University Grossman School of Medicine
- Igor Dolgalev
- Applied Bioinformatics Laboratories, New York University Grossman School of Medicine
- Praveen Agrawal
- Department of Pathology, New York University Grossman School of Medicine
- Gillian Baptiste
- Department of Pathology, New York University Grossman School of Medicine
- David J. Kahler
- High Throughput Biology Core, New York University Grossman School of Medicine
- Elena Sokolova
- Department of Pathology, New York University Grossman School of Medicine
- Sebastian Moran
- Josep Carreras Leukaemia Research Institute (IJC), Badalona
- Laia Piqué
- Josep Carreras Leukaemia Research Institute (IJC), Badalona
- Eleazar Vega-Saenz de Miera
- Interdisciplinary Melanoma Cooperative Group, Perlmutter Cancer Center, New York University School of Medicine
- Barbara Fontanals-Cirera
- Department of Pathology, New York University Grossman School of Medicine
- Alcida Karz
- Department of Pathology, New York University Grossman School of Medicine
- Aristotelis Tsirigos
- Department of Pathology, New York University Grossman School of Medicine
- Chi Yun
- High Throughput Biology Core, New York University Grossman School of Medicine
- Farbod Darvishian
- Department of Pathology, New York University Grossman School of Medicine
- Heather C. Etchevers
- Aix-Marseille University, MMG, Inserm
- Iman Osman
- Interdisciplinary Melanoma Cooperative Group, Perlmutter Cancer Center, New York University School of Medicine
- Manel Esteller
- Josep Carreras Leukaemia Research Institute (IJC), Badalona
- Markus Schober
- Interdisciplinary Melanoma Cooperative Group, Perlmutter Cancer Center, New York University School of Medicine
- Eva Hernando
- Department of Pathology, New York University Grossman School of Medicine
- DOI
- https://doi.org/10.1038/s41467-023-36967-2
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 16
Abstract
Melanocytes can de-differentiate into neural crest cell (NCC)- like states during metastatic melanoma progression. Here the authors compare DNA methylation profiles of NCCs and melanocytes, as well as primary and metastatic patient tissues and identify that DNA methylation changes of NR2F2 isoform 2 influence cell state transitions and melanoma metastatic spread.
