Synthesis and reactivity of some Mannich bases. VIII. Studies on several Mannich bases derived from ortho-hidroxyacetophenones and their conversion into oximino derivatives

Abstract

The synthesis of several Mannich bases resulting from the reaction of 2-hydroxy-4-methylacetophenone with paraformaldehyde and secondary amines is reported. Another series of products was obtained from N,N-dimethyl substituted Mannich bases by replacing the amino group with pyrrolidine. Most of the Mannich bases were transformed into oximes by treatment with hydroxylamine hydrochloride in 10 % NaOH.

Keywords

• ortho-phenolic ketones
• Mannich bases
• amine exchange reaction
• Mannich bases oximes