Regulation of T cell alloimmunity by PI3Kγ and PI3Kδ

Mayuko Uehara; Martina M. McGrath; Shunsuke Ohori; Zhabiz Solhjou; Naima Banouni; Sujit Routray; Catherine Evans; Jonathan P. DiNitto; Abdallah Elkhal; Laurence A. Turka; Terry B. Strom; Stefan G. Tullius; David G. Winkler; Jamil Azzi; Reza Abdi

doi:10.1038/s41467-017-00982-x

Nature Communications (Oct 2017)

Regulation of T cell alloimmunity by PI3Kγ and PI3Kδ

Mayuko Uehara,
Martina M. McGrath,
Shunsuke Ohori,
Zhabiz Solhjou,
Naima Banouni,
Sujit Routray,
Catherine Evans,
Jonathan P. DiNitto,
Abdallah Elkhal,
Laurence A. Turka,
Terry B. Strom,
Stefan G. Tullius,
David G. Winkler,
Jamil Azzi,
Reza Abdi

Affiliations

Mayuko Uehara: Transplantation Research Center, Renal Division, Brigham and Women’s Hospital and Harvard Medical School
Martina M. McGrath: Transplantation Research Center, Renal Division, Brigham and Women’s Hospital and Harvard Medical School
Shunsuke Ohori: Transplantation Research Center, Renal Division, Brigham and Women’s Hospital and Harvard Medical School
Zhabiz Solhjou: Transplantation Research Center, Renal Division, Brigham and Women’s Hospital and Harvard Medical School
Naima Banouni: Transplantation Research Center, Renal Division, Brigham and Women’s Hospital and Harvard Medical School
Sujit Routray: Transplantation Research Center, Renal Division, Brigham and Women’s Hospital and Harvard Medical School
Catherine Evans: Infinity Pharmaceuticals
Jonathan P. DiNitto: Infinity Pharmaceuticals
Abdallah Elkhal: Division of Transplant Surgery and Transplant Surgery Research Laboratory, Brigham and Women’s Hospital and Harvard Medical School
Laurence A. Turka: Center for Transplantation Sciences, Massachusetts General Hospital/Harvard Medical School
Terry B. Strom: The Transplant Institute, Beth Israel Deaconess Medical Center/Harvard Medical School
Stefan G. Tullius: Division of Transplant Surgery and Transplant Surgery Research Laboratory, Brigham and Women’s Hospital and Harvard Medical School
David G. Winkler: Infinity Pharmaceuticals
Jamil Azzi: Transplantation Research Center, Renal Division, Brigham and Women’s Hospital and Harvard Medical School
Reza Abdi: Transplantation Research Center, Renal Division, Brigham and Women’s Hospital and Harvard Medical School

DOI: https://doi.org/10.1038/s41467-017-00982-x
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 11

Abstract

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Phosphatidylinositol-3-kinases (PI3K) γ and δ are key regulators of T cell signaling. Here the author show, using mouse heart allograft transplantation models, that PI3Kγ or PI3Kδ deficiency prolongs graft survival, but selective inhibition of PI3Kγ or PI3Kδ reveals alternative transplant survival outcomes post CTLA4-Ig treatment.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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