Rebamipide: thirty years of experience. A review

Abstract

The review article describes the 30-year practice of using the cytoprotector rebamipide. The use of the drug in South Korea and Russia in various gastrointestinal disorders, including gastroesophageal reflux disease, functional and organic dyspepsia, chronic gastritis, gastric ulcer, including those associated with H. pylori, inflammatory bowel diseases, irritable bowel syndrome, and as a carcinopreventive agent has been demonstrated. Particular attention is paid to drug-induced conditions, given the uncontrolled use of non-steroidal anti-inflammatory drugs and the high prevalence of cardiovascular diseases, which requires the use of antithrombotic drugs with ulcerogenic action.

Keywords

• rebamipide
• non-steroidal anti-inflammatory drugs
• proton pump inhibitors
• gastrointestinal diseases