Nature Communications (May 2017)

Actin stress fiber organization promotes cell stiffening and proliferation of pre-invasive breast cancer cells

  • Sandra Tavares,
  • André Filipe Vieira,
  • Anna Verena Taubenberger,
  • Margarida Araújo,
  • Nuno Pimpao Martins,
  • Catarina Brás-Pereira,
  • António Polónia,
  • Maik Herbig,
  • Clara Barreto,
  • Oliver Otto,
  • Joana Cardoso,
  • José B. Pereira-Leal,
  • Jochen Guck,
  • Joana Paredes,
  • Florence Janody

DOI
https://doi.org/10.1038/ncomms15237
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 18

Abstract

Read online

When cells acquire a malignant phenotype they become less stiff and this helps migration and invasion favouring metastasis. Here the authors show that Src-driven cell transformation and transition to a less stiff state follows an event of membrane stiffening due to stress fibres accumulation.