Alcohol Dehydrogenases as Catalysts in Organic Synthesis

Amanda Silva de Miranda; Cintia D. F. Milagre; Frank Hollmann

doi:10.3389/fctls.2022.900554

Frontiers in Catalysis (May 2022)

Alcohol Dehydrogenases as Catalysts in Organic Synthesis

Amanda Silva de Miranda,
Cintia D. F. Milagre,
Frank Hollmann

Affiliations

Amanda Silva de Miranda: Department of Chemistry, Institute of Exact Sciences, Federal University of Minas Gerais—UFMG, Belo Horizonte, Brazil
Cintia D. F. Milagre: Department of Biochemistry and Organic Chemistry, Institute of Chemistry, UNESP—São Paulo State University, São Paulo, Brazil
Frank Hollmann: Department of Biotechnology, Delft University of Technology, Delft, Netherlands

DOI: https://doi.org/10.3389/fctls.2022.900554
Journal volume & issue: Vol. 2

Abstract

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Alcohol dehydrogenases (ADHs) have become important catalysts for stereoselective oxidation and reduction reactions of alcohols, aldehydes and ketones. The aim of this contribution is to provide the reader with a timely update on the state-of-the-art of ADH-catalysis. Mechanistic basics are presented together with practical information about the use of ADHs. Current concepts of ADH engineering and ADH reactions are critically discussed. Finally, this contribution highlights some prominent examples and future-pointing concepts.

Published in Frontiers in Catalysis

ISSN: 2673-7841 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Chemistry
Website: https://www.frontiersin.org/journals/catalysis

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