Application of a flexible polymer microECoG array to map functional coherence in schizophrenia model
F.Z. Fedor,
A Zátonyi,
D. Cserpán,
Z. Somogyvári,
Z. Borhegyi,
G. Juhász,
Z. Fekete
Affiliations
F.Z. Fedor
Doctoral School of Chemical Engineering and Material Sciences, Pannon University, Veszprém, Hungary; ELTE NAP Neuroimmunology Research Group, Department of Biochemistry, Institute of Biology, Eötvös Loránd University, Budapest, Hungary; Research Group for Implantable Microsystems, Faculty of Information Technology & Bionics, Pázmány Péter Catholic University, Budapest, Hungary
A Zátonyi
ELTE NAP Neuroimmunology Research Group, Department of Biochemistry, Institute of Biology, Eötvös Loránd University, Budapest, Hungary; Centre for Energy Research, Hungarian Academy of Sciences, Budapest, Hungary; Research Group for Implantable Microsystems, Faculty of Information Technology & Bionics, Pázmány Péter Catholic University, Budapest, Hungary
D. Cserpán
Theoretical Neuroscience and Complex Systems Research Group, Department of Computational Sciences, Wigner Research Centre for Physics, Budapest, Hungary
Z. Somogyvári
Theoretical Neuroscience and Complex Systems Research Group, Department of Computational Sciences, Wigner Research Centre for Physics, Budapest, Hungary
Z. Borhegyi
Department of Biochemistry, Eötvös Loránd University, Budapest, Hungary
G. Juhász
Department of Biochemistry, Eötvös Loránd University, Budapest, Hungary
Z. Fekete
Centre for Energy Research, Hungarian Academy of Sciences, Budapest, Hungary; Research Group for Implantable Microsystems, Faculty of Information Technology & Bionics, Pázmány Péter Catholic University, Budapest, Hungary; Corresponding author.
Anatomically, connections form the fundamental brain network, functionally the different types of oscillatory electric activities are creating a temporarily connected fraction of the anatomical connectome generating an output to the motor system. Schizophrenia can be considered as a connectome disease, in which the sensory input generates a schizophrenia specific temporary connectome and the signal processing becomes diseased showing hallucinations and adverse behavioral reactions. In this work, flexible, 32-channel polymer microelectrode arrays fabricated by the authors are used to map the functional coherence on large cortical areas during physiological activities in a schizophrenia model in rats. - Fabrication of a flexible microECoG array is shown. - Protocol to use a flexible microECoG is demonstrated to characterize connectome diseases in rats. - Customized method to analyze the functional coherence between different cortical areas during visually evoked potential is detailed. - R-based implementation of the analysis method is presented.
