Ligand-tethered lipid nanoparticles for targeted RNA delivery to treat liver fibrosis

Xuexiang Han; Ningqiang Gong; Lulu Xue; Margaret M. Billingsley; Rakan El-Mayta; Sarah J. Shepherd; Mohamad-Gabriel Alameh; Drew Weissman; Michael J. Mitchell

doi:10.1038/s41467-022-35637-z

Nature Communications (Jan 2023)

Ligand-tethered lipid nanoparticles for targeted RNA delivery to treat liver fibrosis

Xuexiang Han,
Ningqiang Gong,
Lulu Xue,
Margaret M. Billingsley,
Rakan El-Mayta,
Sarah J. Shepherd,
Mohamad-Gabriel Alameh,
Drew Weissman,
Michael J. Mitchell

Affiliations

Xuexiang Han: Department of Bioengineering, University of Pennsylvania
Ningqiang Gong: Department of Bioengineering, University of Pennsylvania
Lulu Xue: Department of Bioengineering, University of Pennsylvania
Margaret M. Billingsley: Department of Bioengineering, University of Pennsylvania
Rakan El-Mayta: Department of Bioengineering, University of Pennsylvania
Sarah J. Shepherd: Department of Bioengineering, University of Pennsylvania
Mohamad-Gabriel Alameh: Department of Medicine, University of Pennsylvania
Drew Weissman: Department of Medicine, University of Pennsylvania
Michael J. Mitchell: Department of Bioengineering, University of Pennsylvania

DOI: https://doi.org/10.1038/s41467-022-35637-z
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 12

Abstract

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Gene delivery to fibroblasts for liver fibrosis treatment remains challenging. Here the authors develop a combinatorial library of ligand-tethered lipidoids via a modular synthetic method and adopt a 2-round screening strategy to identify lipidoids for potent and selective gene delivery to fibroblasts.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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